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Frequently asked questions in drug combinations and the mass-action law based answers. Drug combination studies and their synergy quantification using the Chou-Talalay method. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands. (Cited 919 times) (45,539 international downloads, as of )

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CompuSyn for Drug Combinations: PC Software and User’s Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC 50 and ED 50 and LD 50 Values, ComboSyn Inc, Paramus, (NJ), 2005. *References and Citation Metrics For total Citations: Google Scholar Citations – Ting-Chao Chou, For total Citing Journals: Thomson Reuters Web of Science (Publons), This website will be unattended, and will not be open to respond to inquiries.īest wishes for your scientific endeavor. The website, will be open to provide general information, a video demo, and illustrated examples of applications, in vitro, in animals, and in clinical trials. The applications of MAL-PD/BD/BI and CI have been extended to radiation, photochemistry, environmental, marine, and agricultural studies as well as the anti-HIV and anti-SARS-CoV-2 drug evaluations. For convenience, some specific examples of design and analysis are also provided in the pulldown menus of this website.įor the updates of search trends and applications of MAL-PD/BD/BI and CI theory, please visit the websites of Google Scholar Citations - Ting-Chao Chou and the Web of Science (Publons), [It is noted that one review article published by Chou in 2006 (3) has now received 4,552 citations in 1,152 different biomedical journals, and one theoretical article introducing the concept of combination index (CI) and its algorithm by Chou & Talalay in 1984 (4) has received 7,504 citations in 1,446 journals, internationally, encompassing broad spectrum of biomedical sciences, including, drugs, chemicals, biologicals, regardless of units, mode or mechanism of actions. 3, 9, 15-18, and in the Appendices of Ref. Examples of “real data analysis” and “sample computer printouts” are available in Refs. The theoretical “Top Down” and the observational “Bottom Up” approaches are conceptually opposite, but purposely complementary for the general biomedical R&D, with distinct quantitative and digital cost-effective features.įor the frequently asked questions (FAQ) on MAL-PD, Biodynamics (BD) and Bioinformatics (BI) for experimental design and the simulated diagnostic plots/graphics, the pitfalls and the most common errors in applying the theory to biomedical research, please refer to Refs. The conventional concept usually uses many dose-data points to fit empirical curve or empirical formula that have no physical or chemical bearings, and rely heavily on statistical analysis for conclusions. By contrast, the conventional biomedical research usually using the “Bottom Up” approach which start with experiments, findings, empirical data analysis, and then hypothesis or speculation. This unique functional dynamics theory/algorithm allows using very few dose-data points to fit the unified general MAL theory, thus to gaining efficiency, cost-effectiveness and automated quantitative simulation. The MAL-PD functional dynamics approach, is an “Top Down” concept with the unified general theory first and applications later. As of, there has been 45,549 downloads by scientists from 137 countries or territories. In 2013, the PD Science LLC was established by Ting-Chao (David) Chou, to take care of scientific affairs of ComboSyn Inc.

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Researchers who are interested and agree with the terms are welcome to register and download the CompuSyn software along with its User’s Guide free of charge.

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On August 1st, 2012, the company announced that as the contribution to the bio-medical research communities, the CompuSyn software has been offered for free download upon registration and adherence to the original terms of usage as indicated in the inner conver of the User's Guide. Dorothy Chou in 2005 with purpose of promoting the pharmacodynamic research and simple computerized analytical simulation using the median-effect principle of the mass-action law (2,3) and its combination index theorem (3,4).ĬomboSyn Inc, which always has vision of not-for–profit purpose, had already recovered the software developmental expense and administration cost. The ComboSyn, Inc., the publisher of CompuSyn software (1), which was set up by Dr.